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    MCQS: Pharmacodynamics Practice Exam Question2s

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    MCQS: Pharmacodynamics Practice Exam Question2s

    مُساهمة من طرف d-forum في 04/01/10, 05:56 pm

    Question # 1 (Multiple Answer) Concerning drug receptor interactions, the constant Kd refers to:

    A) maximal physiological effect
    B) maximal binding
    C) the drug concentration required to occupy 50% of receptors
    D) drug concentration that results in half-maximal physiological response
    E) all of the above

    Question # 2 (Multiple Answer) Signal transduction involves G protein coupled receptor systems:

    A) biogenic amines
    B) peptide hormones
    C) eicosanoids

    Question # 3 (Multiple Choice) Example(s) of second messenger effect(s):

    A) increases in cAMP intracellular concentration
    B) changes in intracellular calcium concentration
    C) phosphoinositide effects
    D) all the above

    Question # 4 (Multiple Choice) EC50 mainly reflexs a drug's:

    A) maximal effect
    B) potency
    C) lethality
    D) ease of elimination
    E) safety

    Question # 5 (Multiple Answer) Physiological processes mediated by the intracellular second messenger, cyclic AMP:

    A) carbohydrate breakdown by the liver
    B) decreased heart rate
    C) increased contractility
    D) smooth muscle relaxation
    E) triglyceride breakdown

    Question # 6 (True/False) Drug effects are thought to be proportional to the number of occupied receptors
    ????: Study Temple-All kinds of Study Material MCQS: Pharmacodynamics Practice Exam Questions

    A) true
    B) false

    Question # 7 (Multiple Choice) Nitric oxide mediates this effect on vascular smooth muscle:

    A) smooth muscle relaxation
    B) smooth muscle contraction
    C) no effect

    Question # 8 (Multiple Choice) Receptors are usually:

    A) lipids
    B) proteins
    C) DNA

    Question # 9 (Multiple Choice) Longer-lasting physiological response to drug:

    A) increase in heart rate following epinephrine infusion
    B) changes in gene product production following corticosteroid injection.

    Question # 10 (Multiple Answer) True statement(s) concerning competitive inhibition:

    A) competitive in addition is based on reversible drug/antagonist binding at receptor sites
    B) with competitive inhibition, the dose-effects curve the shifted to the left
    ????: Study Temple-All kinds of Study Material MCQS: Pharmacodynamics Practice Exam Questions
    C) with competitive inhibition, maximal drug effect cannot be obtained, even at high agonist concentrations
    D) all the above

    Question # 11 (Multiple Answer) Example(s) of endogenous ligands that interact with membrane-integrated ion channels and affect(s) ion conductance.

    A) acetylcholine
    B) GABA
    C) glutamate
    D) aspartate
    E) glycine

    Question # 12 (Multiple Answer) Example(s) of (a) receptor(s) which is/are enzyme(s):

    A) dihydrofolate reductase
    B) acetylcholinesterase
    C) monoamine oxidase

    Question # 13 (Multiple Choice) Primary mechanism by which cAMP effects are terminated:

    A) enzyme-catalyzed dephosphorylation
    B) reuptake into presynaptic nerve terminals

    Question # 14 (Multiple Choice) An example of a receptor which is a structural protein.

    A) Na/K ATPase
    B) acetylcholinesterase
    C) tubulin
    D) DNA
    E) phospholipase C

    Question # 15 (Multiple Choice) An example of an agent that exerts much of its effects through intracellular receptors that in complex form binds to DNA response elements:

    A) acetylcholine
    B) dopamine
    C) corticosteroids
    D) diltiazem
    E) atropine

    Question # 16 (Multiple Choice) Factors that may cause variation in drug responsiveness:

    A) changes in the number or function of receptors
    B) tachyphylaxis
    C) idiosyncratic drug responses
    D) hypersensitivity reactions
    E) all of the above

    Question # 17 (Multiple Answer) Major roles of receptors:

    A) determine rate of drug elimination
    B) determine drug action selectivity
    C) provide a means of blocking drug action as well as mediating drug action
    D) act as drug storage sites


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    Correct Answers


    Quote:

    Question # 1 (Multiple Answer) Concerning drug receptor interactions, the constant Kd refers to:

    (C) the drug concentration required to occupy 50% of receptors


    (D) drug concentration that results in half-maximal physiological response



    Question # 2 (Multiple Answer) Signal transduction involves G protein coupled receptor systems:

    (A) biogenic amines


    (B) peptide hormones


    (C) eicosanoids



    Question # 3 (Multiple Choice) Example(s) of second messenger effect(s):

    Answer: (D) all the above



    Question # 4 (Multiple Choice) EC50 mainly reflexs a drug's:

    Answer: (B) potency



    Question # 5 (Multiple Answer) Physiological processes mediated by the intracellular second messenger, cyclic AMP:

    (A) carbohydrate breakdown by the liver


    (C) increased contractility


    (D) smooth muscle relaxation


    (E) triglyceride breakdown



    Question # 6 (True/False) Drug effects are thought to be proportional to the number of occupied receptors

    Answer: True



    Question # 7 (Multiple Choice) Nitric oxide mediates this effect on vascular smooth muscle:

    Answer: (A) smooth muscle relaxation




    Question # 8 (Multiple Choice) Receptors are usually:

    Answer: (B) proteins

    most commonly proteins; DNA may serve as a receptor for certain agents-- such as certain anticancer drugs.




    Question # 9 (Multiple Choice) Longer-lasting physiological response to drug:

    Answer: (B) changes in gene product production following corticosteroid injection.




    Question # 10 (Multiple Answer) True statement(s) concerning competitive inhibition:

    (A) competitive in addition is based on reversible drug/antagonist binding at receptor sites




    Question # 11 (Multiple Answer) Example(s) of endogenous ligands that interact with membrane-integrated ion channels and affect(s) ion conductance.

    (A) acetylcholine


    (B) GABA


    (C) glutamate


    (D) aspartate


    (E) glycine




    Question # 12 (Multiple Answer) Example(s) of (a) receptor(s) which is/are enzyme(s):

    (A) dihydrofolate reductase


    (B) acetylcholinesterase


    (C) monoamine oxidase



    Question # 13 (Multiple Choice) Primary mechanism by which cAMP effects are terminated:

    Answer: (A) enzyme-catalyzed dephosphorylation





    Question # 14 (Multiple Choice) An example of a receptor which is a structural protein.

    Answer: (C) tubulin




    Question # 15 (Multiple Choice) An example of an agent that exerts much of its effects through intracellular receptors that in complex form binds to DNA response elements:

    Answer: (C) corticosteroids




    Question # 16 (Multiple Choice) Factors that may cause variation in drug responsiveness:

    Answer: (E) all of the above




    Question # 17 (Multiple Answer) Major roles of receptors:

    (B) determine drug action selectivity


    (C) provide a means of blocking drug action as well as mediating drug action



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      الوقت/التاريخ الآن هو 07/12/16, 10:34 am