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    Drug Design of Zinc-Enzyme Inhibitors: Functional, Structural, and Disease Applications

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    تاريخ التسجيل : 28/10/2009
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    Drug Design of Zinc-Enzyme Inhibitors: Functional, Structural, and Disease Applications

    مُساهمة من طرف d-forum في 04/06/10, 06:33 pm

    Drug Design of Zinc-Enzyme Inhibitors:
    Functional, Structural, and Disease Applications





    Drug Design of Zinc-Enzyme Inhibitors:
    Functional, Structural, and Disease Applications

    Wiley | ISBN:
    0470275006 | 2009-08-17 | PDF | 1038 pages | 9 Mb
    Brings together
    functional and structural informationrelevant to the design of drugs
    targeting zinc enzymes
    The second most abundant transition element
    in living organisms, zinc spans all areas of metabolism, with
    zinc-containing proteins offering both established and potential drug
    targets. Drug Design of Zinc-Enzyme Inhibitors brings together
    functional and structural information relevant to these zinc-containing
    targets. With up-to-date overviews of the latest developments field,
    this unique and comprehensive text enables readers to understand zinc
    enzymes and evaluate them in a drug design context.
    With
    contributions from the leaders of today's research, Drug Design of
    Zinc-Enzyme Inhibitors covers such key topics as:
    Major drug targets
    like carbonic anhydrases, matrix metalloproteinases, bacterial
    proteases, angiotensin-converting enzyme, histone deacetylase, and
    APOBEC3G
    Roles of recently discovered zinc-containing isozymes in
    cancer, obesity, epilepsy, pain management, malaria, and other
    conditions
    Cross reactivity of zinc-enzyme inhibitors and activators
    The extensive use of X-ray crystallography and QSAR studies for
    understanding zinc-containing proteins
    Clinical applications
    An
    essential resource for the discovery and development of new drug
    molecules, Drug Design of Zinc-Enzyme Inhibitors gives researchers,
    professionals, students, and academics the foundation to understand and
    work with zinc enzyme inhibitors and activators.

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